Galleria mellonella apolipophorin III – an apolipoprotein with anti-Legionella pneumophila activity
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منابع مشابه
Anti-Legionella dumoffii Activity of Galleria mellonella Defensin and Apolipophorin III
The gram-negative bacterium Legionella dumoffii is, beside Legionella pneumophila, an etiological agent of Legionnaires' disease, an atypical form of pneumonia. The aim of this study was to determine the antimicrobial activity of Galleria mellonella defense polypeptides against L. dumoffii. The extract of immune hemolymph, containing a mixture of defense peptides and proteins, exhibited a do...
متن کاملLegionella pneumophila pathogenesis in the Galleria mellonella infection model.
Legionella pneumophila is a facultative intracellular human pathogen and the etiological agent of severe pneumonia known as Legionnaires' disease. Its virulence depends on protein secretion systems, in particular, the Dot/Icm type IV secretion system (T4SS), which is essential to establish a replication-permissive vacuole in macrophages. The analysis of the role of these systems and their subst...
متن کاملUse of Galleria mellonella as a Model Organism to Study Legionella pneumophila Infection
Legionella pneumophila, the causative agent of a severe pneumonia named Legionnaires' disease, is an important human pathogen that infects and replicates within alveolar macrophages. Its virulence depends on the Dot/Icm type IV secretion system (T4SS), which is essential to establish a replication permissive vacuole known as the Legionella containing vacuole (LCV). L. pneumophila infection can ...
متن کاملThe effect of Galleria mellonella hemolymph polypeptides on Legionella gormanii.
Among Legionella species, which are recognized to be pathogenic for humans, L. gormanii is the second prevalent causative agent of community-acquired pneumonia after L. pneumophila. Anti-L. gormanii activity of Galleria mellonella hemolymph extract and apolipophorin III (apoLp-III) was examined. The extract and apoLp-III at the concentration 0.025 mg/ml caused 75% and 10% decrease of the bacter...
متن کاملDifferences in Virulence Between Legionella pneumophila Isolates From Human and Non-human Sources Determined in Galleria mellonella Infection Model
Citation: Sousa PS, Silva IN, Moreira LM, Veríssimo A and Costa J (2018) Differences in Virulence Between Legionella pneumophila Isolates From Human and Non-human Sources Determined in Galleria mellonella Infection Model. Front. Cell. Infect. Microbiol. 8:97. doi: 10.3389/fcimb.2018.00097 Differences in Virulence Between Legionella pneumophila Isolates From Human and Non-human Sources Determine...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2014
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2014.07.003